In 2048, on an Earth overpopulated and driven by violent conflicts, scientists are looking to Saturn's moon Titan as a new home for humanity, spearheaded by Professor Martin Collingwood.<br /><br />Rick Janssen, a U.S. Air Force fighter pilot, volunteers to be a part of an experiment on 14 test subjects that forces human bodies to adapt to the super-cold methane liquids and the ultra-low oxygen atmosphere of Titan. He is joined by his wife Abigail, a medical researcher, and their son Lucas, at the Titan I research area. The initial results are promising. Rick becomes able to swim at incredible speeds and stay underwater for 42 minutes.<br /><br />Rick's training becomes increasingly intense as he and the others adapt to increasingly Titan-like environments. Rick finds that some of his hair is falling out, and one of the team members starts convulsing and dies. Abigail notices the veins of all the test subjects becoming darker. Fellow volunteer Zane has a mental breakdown which causes him to attack his wife, Rayenne.<br /><br />Rick takes a break by sitting at the bottom of their swimming pool, where large amounts of his skin are shed. Abigail's concern grows, and she begins experimentation on a sample of his blood, finding that it is indeed becoming darker. Rick undergoes corneal surgery to accommodate the low light on Titan. When he later has complications, Abigail confronts Collingwood about Rick's changes, but he divulges nothing.<br /><br />Zane suffers another mental breakdown and throws Rayenne through a window, killing her instantly. He is shot and killed by military police. While visiting Rick in the medical facility, Abigail steals his key card and sneaks into Collingwood's office. She finds reports of autopsies of the numerous deceased test subjects, discovering that they were having their DNA infused with animal DNA in an attempt to create the next human species, Homo titaniens.<br /><br />During a meeting with NASA, Collingwood is chastised for doing forced evolutionary experimentation without proper evidence or ethical reasons, and is threatened with having his operation shut down. Abigail confronts him on the same issue, and he admits to her and Rick that he does not actually know what the surviving subjects will eventually become.<br /><br />Rick willingly undergoes major surgery to adapt to his new senses and become fully ready for Titan. He and Tally, the only other surviving test subject, complete their training and finish their transformations into Homo titaniens. Abigail is horrified when the significantly-transformed Rick loses the ability to talk, now communicating in a low frequency that is undetectable by normal human ears.<br /><br />Tally kills her husband, later visiting Rick at his home. Abigail and Lucas hide while military police surround Tally and Rick. Tally kills a member of the police before she is killed, and then Rick easily kills many more. When Abigail and Lucas confront him, Rick flees, realizing what he has become.
